Neutrophil-intrinsic control of immune activity

Because neutrophils operate with poor target precision, their activity must be tightly controlled. Recently, we showed that the transcription factor PU.1 shields the chromatin from indiscriminate transcriptional activity, thus safeguarding neutrophils from carrying out an inappropriate immune response. Yet, how neutrophils overcome this PU.1-instructed ‘chromatin barrier’ in infectious situations remains unexplored. Hence, we will here study epigenetic mechanisms operating in neutrophils to fine-tune their activity states during infection and inflammation.

Rosenbauer
Frank, PhD

UniMS

Institute of Molecular Tumour Biology

Team

Aleth
Hanna, PhD student

UniMS

Publications

A1 A2 B2 B3 C1 C3 C6 C7 Z1 The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke Severity Strecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J. 2025 bioRxiv https://doi.org/10.1101/2025.09.19.677282
A1 A2 B2 B3 C1 C6 INF Neutrophil Progenitor Mobilization Is a Distinct Feature of STEMI and Predicts Survival Richter, M.; Von Göwels, J.; Fähndrich, M.; Fernandez, C. L.; Grohn, K.; Schwarz, D.; Lang, A.; Polzin, A.; Farinola, L.; Gosh, S.; Groba, S. R.; Heming, J.-N.; Aleth, H.; Rübsamen, N.; Radecke, T.; Rosenbauer, F.; Sickmann, A.; Karch, A.; Zarbock, A.; Minnerup, J.; Sindermann, J.; Bender, A.; Rossaint, J.; Ormanns, S.; Gunzer, M.; Reinecke, H.; Makowski, L.; Jung, C.; Silvestre-Roig, C.; Kelm, M.; Gerdes, N.; Chevre, R.; Lange, S.; Soehnlein, O. 2025 Research Square https://doi.org/10.21203/rs.3.rs-6474581/v2
B3 C7 Redistribution of PU.1 Partner Transcription Factor RUNX1 Binding Secures Cell Survival during Leukemogenesis Bender, A.; Boydere, F.; Jayavelu, A. K.; Tibello, A.; König, T.; Aleth, H.; Meyer Zu Hörste, G.; Vogl, T.; Rosenbauer, F. 2024 EMBO J https://doi.org/10.1038/s44318-024-00295-y
A2 A3 A4 A5 A6 A7 B1 B2 B3 B5 C1 C2 C3 C5 AP1 Neutrophils - Biology and Diversity Maier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium. 2023 Nephrol Dial Transplant https://doi.org/10.1093/ndt/gfad266